Details of Metabolite

General Information of MET (ID: META00553)
Name Tetradecanoylcarnitine
Synonyms   Click to Show/Hide Synonyms of This Metabolite
(-)-Myristoylcarnitine; (-)-Tetradecanoylcarnitine; (R)-Myristoylcarnitine; (R)-Tetradecanoylcarnitine; C14 Carnitine; L-Myristoylcarnitine; Myristoyl-L-(-)-carnitine; Myristoyl-L-carnitine; Myristoylcarnitine; O-Tetradecanoyl-(R)-carnitine; Tetradecanoyl-L-carnitine; Tetradecanoylcarnitine
Source Aliphatic acyclic compounds
Structure Type   Fatty acid esters  (Click to Show/Hide the Complete Structure Type Hierarchy)
Lipids and lipid-like molecules
Fatty Acyls
Fatty acid esters
PubChem CID
53477791
HMDB ID
HMDB0005066
Formula
C21H41NO4
Structure
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3D MOL is unavailable 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
ChEBI ID
84634
FooDB ID
FDB023615
ChemSpider ID
30776567
Physicochemical Properties Molecular Weight 371.6 Topological Polar Surface Area 66.4
XlogP 6.6 Complexity 371
Heavy Atom Count 26 Rotatable Bond Count 17
Hydrogen Bond Donor Count N.A. Hydrogen Bond Acceptor Count 4
Function
Tetradecanoylcarnitine, also known as myristoylcarnitine, is a member of the class of compounds known as acylcarnitines. Acylcarnitines are organic compounds containing a fatty acid with the carboxylic acid attached to carnitine through an ester bond. Acylcarnitines are useful in the diagnosis of genetic disorders such as fatty acid oxidation disorders and differentiation between biochemical phenotypes of medium-chain acyl-CoA dehydrogenase (MCAD) deficiency disorders. Tetradecanoylcarnitine is involved in the beta-oxidation of long-chain fatty acids. Tetradecanoylcarnitine is found to be associated with glutaric aciduria II, which is an inborn error of metabolism.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Oxidoreductases (EC 1)
            Formyltetrahydrofolate dehydrogenase (ALDH1L2) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Mutation of ALDH1L2
                      Induced Change Tetradecanoylcarnitine concentration: increase (FC = 6.25)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Genetic disorders of keratinisation [ICD-11: EC20]
                      Details It is reported that mutation (patients) of ALDH1L2 leads to the increase of tetradecanoylcarnitine levels compared with control group.
References
1 Deleterious mutations in ALDH1L2 suggest a novel cause for neuro-ichthyotic syndrome. NPJ Genom Med. 2019 Jul 23;4:17.

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