Details of Metabolite

General Information of MET (ID: META00543)
Name N2,N2-Dimethylguanosine
Synonyms   Click to Show/Hide Synonyms of This Metabolite
2,2-Dimethylguanosine; 2-(Dimethylamino)-9-(beta-D-ribofuranosyl)-1,9-dihydro-6H-purin-6-one; 2-Dimethylamino-6-oxypurine riboside; N(2),N(2)-Dimethylguanosine; N,N- Dimethylguanosine; N,N-Dimethyl-guanosine; N2,N2-Dimethylguanosine; N2-Dimethylguanosine; m(2)(2)g; m(2)2g; m2(2)g; m22g
Source Endogenous;Food
Structure Type   Purine nucleosides  (Click to Show/Hide the Complete Structure Type Hierarchy)
Nucleosides, nucleotides, and analogues
Purine nucleosides
PubChem CID
92919
HMDB ID
HMDB0004824
Formula
C12H17N5O5
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
ChEBI ID
19289
FooDB ID
FDB023432
ChemSpider ID
83878
METLIN ID
7086
Physicochemical Properties Molecular Weight 311.2939 Topological Polar Surface Area N.A.
XlogP N.A. Complexity N.A.
Heavy Atom Count N.A. Rotatable Bond Count N.A.
Hydrogen Bond Donor Count N.A. Hydrogen Bond Acceptor Count N.A.
Function
N2,N2-Dimethylguanosine is an urinary nucleoside, a primary degradation product of tRNA. The mean levels of urinary N2,N2-Dimethylguanosine in the patients with colorectal cancer are significantly higher than those in patients with intestinal villous adenoma or the healthy adults. N2,N2-Dimethylguanosine has been identified in the human placenta.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Pore-forming PNC peptide (PNC)
            Cellular tumor antigen p53 (TP53) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of TP53
                      Induced Change N2,N2-Dimethylguanosine concentration: decrease (Log2 FC=0.84)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Colon cancer [ICD-11: 2B90]
                      Details It is reported that knockout of TP53 leads to the decrease of N2,N2-dimethylguanosine levels compared with control group.
      Transferases (EC 2)
            Arylamine N-acetyltransferase 1 (NAT1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Knockout of NAT1
                      Induced Change N2,N2-Dimethylguanosine concentration: decrease (FC = 0.4)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Breast cancer [ICD-11: 2C60]
                      Details It is reported that knockout of NAT1 leads to the decrease of N2,N2-dimethylguanosine levels compared with control group.
References
1 Integrative omics analysis of p53-dependent regulation of metabolism. FEBS Lett. 2018 Feb;592(3):380-393.
2 CRISPR/Cas9 knockout of human arylamine N-acetyltransferase 1 in MDA-MB-231 breast cancer cells suggests a role in cellular metabolism. Sci Rep. 2020 Jun 17;10(1):9804.

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