Details of Metabolite

General Information of MET (ID: META00542)
Name FAPy-adenine
Synonyms   Click to Show/Hide Synonyms of This Metabolite
4,6-Diamino-5-(formylamino)pyrimidine; 4,6-Diamino-5-N-formamidopyrimidine; 4,6-Diamino-5-formamidopyrimidine; 4,6-Diamino-5-pyrimidinylformamide; FAPY; FAPy-adenine; Fapyade; N-(4,6-Diamino-5-pyrimidinyl)-formamide; N-(4,6-Diamino-5-pyrimidinyl)formamide
Source Endogenous;Food
Structure Type   Pyrimidines and pyrimidine derivatives  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organoheterocyclic compounds
Diazines
Pyrimidines and pyrimidine derivatives
PubChem CID
114926
HMDB ID
HMDB0004816
Formula
C5H7N5O
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C06502
ChEBI ID
27983
FooDB ID
FDB023426
ChemSpider ID
102870
METLIN ID
7080
Physicochemical Properties Molecular Weight 153.14 Topological Polar Surface Area 107
XlogP -1.3 Complexity 131
Heavy Atom Count 11 Rotatable Bond Count 1
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 5
Function
Fapy-adenine is an oxidized DNA base. Oxidized nucleosides are biochemical markers for tumors, aging, and neurodegenerative diseases. Oxidative stress damage to DNA bases may contribute to neuronal loss in Alzheimer's disease (AD). Increased levels were observed in parietal, temporal, occipital, and frontal lobe, superior temporal gyrus, and hippocampus areas of the brain in patients with AD.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Hydrolases (EC 3)
            GTPase KRas (KRAS) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Overexpression of KRAS
                      Induced Change FAPy-adenine concentration: decrease (FC = 0.23)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Lung cancer [ICD-11: 2C25]
                      Details It is reported that overexpression of KRAS leads to the decrease of FAPy-adenine levels compared with control group.
References
1 Capturing the metabolomic diversity of KRAS mutants in non-small-cell lung cancer cells. Oncotarget. 2014 Jul 15;5(13):4722-31.

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