General Information of MET (ID: META00513)
Name GDP-glucose
Synonyms   Click to Show/Hide Synonyms of This Metabolite
(GDP-GLC)1; GDP Glucose; GDP-D-glucose; GDP-alpha-D-glucose; GDP-glucose; GDPG; Guanosine 5-pyrophosphate; Guanosine diphosphate glucose; Guanosine diphosphate glucose, (D)-isomer; Guanosine diphosphoglucose; Guanosine diphosphoric acid glucose; P-alpha-D-Glucopyranosyl ester
Source Endogenous;Food
Structure Type   Purine nucleotide sugars  (Click to Show/Hide the Complete Structure Type Hierarchy)
Nucleosides, nucleotides, and analogues
Purine nucleotides
Purine nucleotide sugars
PubChem CID
644106
HMDB ID
HMDB0003351
Formula
C16H25N5O16P2
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C00394
ChEBI ID
62254
FooDB ID
FDB023150
ChemSpider ID
559146
METLIN ID
6900
Physicochemical Properties Molecular Weight 605.3411 Topological Polar Surface Area N.A.
XlogP N.A. Complexity N.A.
Heavy Atom Count N.A. Rotatable Bond Count N.A.
Hydrogen Bond Donor Count N.A. Hydrogen Bond Acceptor Count N.A.
Function
GDP-glucose is a substrate for Uridine diphosphate glucose pyrophosphatase.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Transcription factor (TF)
            Forkhead box protein O1 (FOXO1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Overexpression of Foxo1
                      Induced Change GDP-glucose concentration: increase (FC = 1.70)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of Foxo1 leads to the increase of GDP-glucose levels compared with control group.
References
1 Metabolomic analysis of C2C12 myoblasts induced by the transcription factor FOXO1. FEBS Lett. 2019 Jun;593(12):1303-1312.

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