General Information of MET (ID: META00437)
Name Pyridoxal 5'-phosphate
Synonyms   Click to Show/Hide Synonyms of This Metabolite
3-Hydroxy-2-methyl-5-[(phosphonooxy)methyl]-4-pyridinecarboxaldehyde; 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde 5-phosphate; Biosechs; Codecarboxylase; Coenzyme b6; Hairoxal; Hexermin-p; Hi-pyridoxin; Hiadelon; Himitan; PAL-p; PLP', Pyridoxal 5'-(dihydrogen phosphate), 'Pyridoxal 5-monophosphoric acid ester; Phosphate mono-(4-formyl-5-hydroxy-6-methyl-pyridin-3-ylmethyl) ester', Pyridoxal 5'-(dihydrogen phosphoric acid), 'Pyridoxal 5-monophosphate ester; Phosphate, pyridoxal; Phosphopyridoxal; Phosphopyridoxal coenzyme; Phosphoric acid mono-(4-formyl-5-hydroxy-6-methyl-pyridin-3-ylmethyl) ester; Pidopidon; Piodel; Pydoxal; Pyridoxal 5 phosphate; Pyridoxal 5-phosphate; Pyridoxal 5-phosphoric acid; Pyridoxal p; Pyridoxal phosphate', PYRIDOXAL-5'-phosphATE, '3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde 5-phosphoric acid; Pyridoxal phosphoric acid', PYRIDOXAL-5'-phosphoric acid, Pyridoxal 5'-phosphoric acid, 'Apolon b6; Pyridoxal-p; Pyridoxyl phosphate; Pyromijin; Sechvitan; Vitahexin-p; Vitazechs
Source Endogenous;Escherichia Coli Metabolite;Yeast Metabolite;Food;Drug;Cosmetic;Microbial
Structure Type   Pyridine carboxaldehydes  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organoheterocyclic compounds
Pyridines and derivatives
Pyridine carboxaldehydes
PubChem CID
1051
HMDB ID
HMDB0001491
Formula
C8H10NO6P
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C00018
DrugBank ID
DB00114
ChEBI ID
18405
FooDB ID
FDB021820
ChemSpider ID
1022
METLIN ID
6275
Physicochemical Properties Molecular Weight 247.14 Topological Polar Surface Area 117
XlogP -1.1 Complexity 292
Heavy Atom Count 16 Rotatable Bond Count 4
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 7
Function
This is the active form of vitamin B6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (pyridoxamine). -- Pubchem; Pyridoxal-phosphate (PLP, pyridoxal-5'-phosphate) is a cofactor of many enzymatic reactions. It is the active form of vitamin B6 which comprises three natural organic compounds, pyridoxal, pyridoxamine and pyridoxine. -- Wikipedia.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      GPCR secretin (GPCR-2)
            Glucagon receptor (GCGR) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of Gcgr
                      Induced Change Pyridoxal 5'-phosphate concentration: increase (FC = 1.5)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Type 2 diabetes mellitus [ICD-11: 5A11]
                      Details It is reported that knockout of GCGR leads to the increase of pyridoxal 5'-phosphate levels compared with control group.
References
1 Polyomic profiling reveals significant hepatic metabolic alterations in glucagon-receptor (GCGR) knockout mice: implications on anti-glucagon therapies for diabetes. BMC Genomics. 2011 Jun 1;12:281.

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