General Information of MET (ID: META00429)
Name Pyridoxamine
Synonyms   Click to Show/Hide Synonyms of This Metabolite
2-Methyl-4-aminomethyl-5-hydroxymethyl-3-pyridinol; 4-(AMINOMETHYL)-5-(hydroxymethyl)-2-methylpyridin-3-ol; 4-(Aminomethyl)-5-(hydroxymethyl)-2-methyl-3-pyridinol; 4-(Aminomethyl)-5-hydroxy-6-methyl-3-pyridinemethanol; PM; Pyridoxylamine
Source Endogenous;Escherichia Coli Metabolite;Yeast Metabolite;Food;Microbial
Structure Type   Pyridoxamines  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organoheterocyclic compounds
Pyridines and derivatives
Pyridoxamines
PubChem CID
1052
HMDB ID
HMDB0001431
Formula
C8H12N2O2
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=1052"></iframe>
3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C00534
DrugBank ID
DB11673
ChEBI ID
16410
FooDB ID
FDB021819
ChemSpider ID
1023
METLIN ID
238
Physicochemical Properties Molecular Weight 168.19 Topological Polar Surface Area 79.4
XlogP -1 Complexity 143
Heavy Atom Count 12 Rotatable Bond Count 2
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 4
Function
The 4-aminomethyl form of vitamin B6. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate. -- Pubchem; Pyridoxamine is one of the compounds that can be called vitamin B6, along with Pyridoxal and Pyridoxine. -- Wikipedia.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Lyases (EC 4)
            Cystathionine gamma-lyase (CTH) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of Cth
                      Induced Change Pyridoxamine concentration: increase (FC = 2.91)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Organic acid disorderss [ICD-11: 5C50]
                      Details It is reported that knockout of Cth leads to the increase of pyridoxamine levels compared with control group.
References
1 Hydrogen Sulfide Is a Regulator of Hemoglobin Oxygen-Carrying Capacity via Controlling 2,3-BPG Production in Erythrocytes. Oxid Med Cell Longev. 2021 Feb 13;2021:8877691.

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