Details of Metabolite

General Information of MET (ID: META00425)
Name dUMP
Synonyms   Click to Show/Hide Synonyms of This Metabolite
2'-Deoxyuridine 5'-monophosphate, 2'-Deoxyuridine 5'-phosphate, Deoxyuridine 5'-phosphate, 'Deoxyuridine monophosphate; Deoxyuridylate; Deoxyuridylic acid', 2'-Deoxyuridine 5'-monophosphoric acid, 2'-Deoxyuridine 5'-phosphoric acid, Deoxyuridine 5'-phosphoric acid, 'Deoxyuridine monophosphoric acid', 2'-Deoxy-5'-uridylate, 2'-Deoxy-5'-uridylic acid, 2'-Deoxyuridylate, 2'-Deoxyuridylic acid, 'Deoxy-UMP', Deoxyuridine 5'-monophosphate, 2'-Deoxyuridine-5'-monophosphate, 2'-Deoxyuridylic acid, disodium salt
Source Endogenous;Escherichia Coli Metabolite;Yeast Metabolite;Food;Drug;Microbial
Structure Type   Pyrimidine deoxyribonucleotides  (Click to Show/Hide the Complete Structure Type Hierarchy)
Nucleosides, nucleotides, and analogues
Pyrimidine nucleotides
Pyrimidine deoxyribonucleotides
PubChem CID
65063
HMDB ID
HMDB0001409
Formula
C9H13N2O8P
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C00365
DrugBank ID
DB03800
ChEBI ID
17622
FooDB ID
FDB022604
ChemSpider ID
58574
METLIN ID
6225
Physicochemical Properties Molecular Weight 308.18 Topological Polar Surface Area 146
XlogP -3.3 Complexity 488
Heavy Atom Count 20 Rotatable Bond Count 4
Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 8
Function
dUMP is formed by the reduction of ribonucleotides to deoxyribonucleotides by ribonucleoside diphosphate reductase [EC 1.17.4.1]. dUMP by the action of by thymidylate synthetase [EC 2.1.1.45] produces dTMP (5,10-Methylene-5,6,7,8-tetrahydrofolate is a cofactor for the reaction). The nuclear form of uracil-DNA glycosylase (UNG2), that its major role is to remove misincorporated dUMP residues (cells deficient in removal of misincorporated dUMP accumulate uracil residues).
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Mitochondrial carrier (MC)
            Solute carrier family 25 member 36 (SLC25A36) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Recombinant protein addition of SLC25A36
                      Induced Change dUMP concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that recombinant protein addition of SLC25A36 leads to the increase of dUMP levels compared with control group.
References
1 The human SLC25A33 and SLC25A36 genes of solute carrier family 25 encode two mitochondrial pyrimidine nucleotide transporters. J Biol Chem. 2014 Nov 28;289(48):33137-48.

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