Details of Metabolite

General Information of MET (ID: META00424)
Name Niacinamide
Synonyms   Click to Show/Hide Synonyms of This Metabolite
3 Pyridinecarboxamide; 3-Carbamoylpyridine; 3-Pyridinecarboxamide; 3-Pyridinecarboxylic acid amide; Acid amide; Amid kyseliny nikotinove; Amide PP; Aminicotin; Amixicotyn; Amnicotin; Astra brand OF niacinamide; Austrovit PP; Benicot; Delonin amide; Dipegyl; Dipigyl; Endobion; Factor PP; Hansamid; Inovitan PP; Mediatric; Merck brand OF niacinamide; NAM; Nandervit-N; Niacevit; Niacin; Niacinamide; Niacinamide astra brand; Niacinamide jenapharm brand; Niacinamide merck brand; Niacinamide pharmagenix brand; Niamide; Niavit PP; Nicamide; Nicamina; Nicamindon; Nicasir; Nicobion; Nicofort; Nicogen; Nicomidol; Nicosan 2; Nicosylamide; Nicota; Nicotamide; Nicotilamide; Nicotililamido; Nicotinamid; Nicotinamida; Nicotinamide; Nicotinamidum; Nicotinate amide; Nicotine acid amide; Nicotine amide; Nicotinic acid amide; Nicotinic amide; Nicotinsaeureamid; Nicotinsaureamid; Nicotol; Nicotylamide; Nicotylamidum; Nicovel; Nicovit; Nicovitina; Nicovitol; Nicozymin; Nictoamide; Niko-tamin; Nikotinamid; Nikotinsaeureamid; Niocinamide; Niozymin; PP-Faktor; Papulex; Pelmin; Pelmine; Pelonin amide; Pharmagenix brand OF niacinamide; Propamine a; Pyridine-3-carboxylic acid amide; Savacotyl; Vi-nicotyl; Vi-noctyl; Vitamin PP; Vitamin b 3; Vitamin b3; Witamina PP; b 3, Vitamin; b3, Vitamin; beta-Pyridinecarboxamide; m-(Aminocarbonyl)pyridine
Source Endogenous;Escherichia Coli Metabolite;Yeast Metabolite;Food;Carcinogenic Potency;Drug;Toxins/Pollutant;Cosmetic;Food additives;TCM Ingredients;Microbial
Structure Type   Pyridinecarboxylic acids and derivatives  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organoheterocyclic compounds
Pyridines and derivatives
Pyridinecarboxylic acids and derivatives
PubChem CID
936
HMDB ID
HMDB0001406
Formula
C6H6N2O
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C00153
DrugBank ID
DB02701
ChEBI ID
17154
FooDB ID
FDB012485
ChemSpider ID
911
METLIN ID
1497
Physicochemical Properties Molecular Weight 122.12 Topological Polar Surface Area 56
XlogP -0.4 Complexity 114
Heavy Atom Count 9 Rotatable Bond Count 1
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 2
Function
Niacinamide or vitamin B3 is an important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and pellagra. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake. Niacinamide is used to increase the effect of radiation therapy on tumor cells. Niacin (nicotinic acid) and niacinamide, while both labeled as vitamin B3 also have different applications. Niacinamide is useful in arthritis and early-onset type I diabetes while niacin is an effective reducer of high cholesterol levels. Niacinamide has been identified as a uremic toxin according to the European Uremic Toxin Working Group.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Hydrolases (EC 3)
            GTPase KRas (KRAS) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Overexpression of KRAS
                      Induced Change Niacinamide concentration: decrease (FC = 0.53)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Lung cancer [ICD-11: 2C25]
                      Details It is reported that overexpression of KRAS leads to the decrease of niacinamide levels compared with control group.
      Pore-forming PNC peptide (PNC)
            Cellular tumor antigen p53 (TP53) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Knockout of TP53
                      Induced Change Niacinamide concentration: decrease (Log2 FC=0.55)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Colon cancer [ICD-11: 2B90]
                      Details It is reported that knockout of TP53 leads to the decrease of niacinamide levels compared with control group.
References
1 Capturing the metabolomic diversity of KRAS mutants in non-small-cell lung cancer cells. Oncotarget. 2014 Jul 15;5(13):4722-31.
2 Integrative omics analysis of p53-dependent regulation of metabolism. FEBS Lett. 2018 Feb;592(3):380-393.

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