Details of Metabolite

General Information of MET (ID: META00398)
Name Glyceric acid 1,3-biphosphate
Synonyms   Click to Show/Hide Synonyms of This Metabolite
(R)-2-Hydroxy-3-(phosphonooxy)-1-monoanhydride with phosphoric propanoate; (R)-2-Hydroxy-3-(phosphonooxy)-1-monoanhydride with phosphoric propanoic acid; 1,3-Biphosphoglycerate; 1,3-Bisphospho-D-glycerate; 1,3-Bisphospho-D-glyceric acid; 1,3-Bisphosphoglycerate; 1,3-Bisphosphoglyceric acid; 1,3-Diphosphoglycerate; 1,3-Diphosphoglyceric acid; 3-Phospho-D-glyceroyl dihydrogen phosphoric acid; 3-Phospho-D-glyceroyl phosphate; 3-Phospho-D-glyceroyl phosphoric acid; 3-Phospho-D-glyceroyl-phosphate; 3-Phosphoglyceroyl phosphate; 3-Phosphoglyceroyl-p; 3-Phosphoglyceroyl-phosphate; 3-Phosphonato-D-glyceroyl phosphate; 3-Phosphonatoglyceroyl phosphate; 3-p-Glyceroyl-p; D-Glycerate 1,3-biphosphate; D-Glycerate 1,3-bisphosphate; D-Glycerate 1,3-diphosphate; D-Glyceric acid 1,3-biphosphate; D-Glyceric acid 1,3-bisphosphate; D-Glyceric acid 1,3-diphosphate; D-Glyceric acid 1,3-diphosphoric acid; DPG; Glycerate 1,3-biphosphate; Glycerate 1,3-bisphosphate; Glycerate 1,3-diphosphate; Glyceric acid 1,3-biphosphate; Glyceric acid 1,3-biphosphoric acid; Glyceric acid 1,3-bisphosphate; Glyceric acid 1,3-diphosphate; Phosphoglyceroyl-p; p-Glyceroyl-p
Source Endogenous;Escherichia Coli Metabolite;Yeast Metabolite;Food;Microbial
Structure Type   Phosphate esters  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic acids and derivatives
Organic phosphoric acids and derivatives
Phosphate esters
PubChem CID
439191
HMDB ID
HMDB0001270
Formula
C3H8O10P2
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C00236
ChEBI ID
16001
FooDB ID
FDB030188
Physicochemical Properties Molecular Weight 266.04 Topological Polar Surface Area 171
XlogP -3.9 Complexity 311
Heavy Atom Count 15 Rotatable Bond Count 6
Hydrogen Bond Donor Count 5 Hydrogen Bond Acceptor Count 10
Function
Glyceric acid 1,3-biphosphate (CAS: 1981-49-3), also known as 1,3-bisphosphoglycerate (1,3BPG) or PGAP, is a 3-carbon organic molecule present in most, if not all living creatures. It primarily exists as a metabolic intermediate in glycolysis during respiration. 1,3BPG has been recognized as regulatory signal implicated in the control of metabolism, oxygen affinity of red cells, and other cellular functions. 1,3BPG concentration in erythrocytes changes in a number of pathological conditions, such as inherited phosphoglycerate kinase deficiency in erythrocytes (involved in the synthesis and breakdown of 1,3BPG). Glyceric acid 1,3-biphosphate is phosphorylated at the number 1 and 3 carbons. The result of this phosphorylation gives 1,3BPG important biological properties such as the ability to phosphorylate ADP to form the energy storage molecule ATP.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Oxidoreductases (EC 1)
            L-2-hydroxyglutarate dehydrogenase (L2HGDH) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Mutation (Nonsense mutations or missense mutations) of L2hgdh
                      Induced Change Glyceric acid 1,3-biphosphate concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Melanoma [ICD-11: 2C30]
                      Details It is reported that mutation (nonsense mutations or missense mutations leading to KMT2D loss) of L2hgdh leads to the increase of glyceric acid 1,3-biphosphate levels compared with control group.
References
1 Enhancer Reprogramming Confers Dependence on Glycolysis and IGF Signaling in KMT2D Mutant Melanoma. Cell Rep. 2020 Oct 20;33(3):108293.

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