Details of Metabolite

General Information of MET (ID: META00397)
Name Methylmalonyl-CoA
Synonyms   Click to Show/Hide Synonyms of This Metabolite
(R)-Methylmalonyl-CoA; (R)-Methylmalonyl-coenzyme A; (S)-2-Methyl-3-oxopropanoyl-CoA; (S)-Methyl-malonyl-CoA; (S)-Methyl-malonyl-coenzyme A; CH3-Malonyl-CoA; CH3-Malonyl-coenzyme A; D-Methylmalonyl-CoA; D-Methylmalonyl-coenzyme A; L-Methylmalonyl-CoA; L-Methylmalonyl-coenzyme A; Methyl-malonyl-coenzyme A
Source Endogenous;Escherichia Coli Metabolite;Food;Microbial
Structure Type   Fatty acyl thioesters  (Click to Show/Hide the Complete Structure Type Hierarchy)
Lipids and lipid-like molecules
Fatty Acyls
Fatty acyl thioesters
PubChem CID
439291
HMDB ID
HMDB0001269
Formula
C25H40N7O19P3S
Structure
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3D MOL is unavailable 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C00683
ChEBI ID
15466
FooDB ID
FDB022523
ChemSpider ID
388424
METLIN ID
462
Physicochemical Properties Molecular Weight 867.6 Topological Polar Surface Area 426
XlogP -5.4 Complexity 1530
Heavy Atom Count 55 Rotatable Bond Count 22
Hydrogen Bond Donor Count 10 Hydrogen Bond Acceptor Count 24
Function
Methylmalonyl-CoA is an intermediate in the metabolism of Propanoate. It is a substrate for Malonyl-CoA decarboxylase (mitochondrial), Methylmalonyl-CoA mutase (mitochondrial) and Methylmalonyl-CoA epimerase (mitochondrial).
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Lyases (EC 4)
            Ethylmalonyl-CoA decarboxylase (ECHDC1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Overexpression of Echdc1
                      Induced Change Methylmalonyl-CoA concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of Echdc1 leads to the decrease of methylmalonyl-CoA levels compared with control group.
References
1 The synthesis of branched-chain fatty acids is limited by enzymatic decarboxylation of ethyl- and methylmalonyl-CoA. Biochem J. 2019 Aug 30;476(16):2427-2447.

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