Details of Metabolite

General Information of MET (ID: META00369)
Name D-Sedoheptulose 7-phosphate
Synonyms   Click to Show/Hide Synonyms of This Metabolite
D-Sedoheptulose 7-phosphate; D-altro-Heptulose 7-phosphate; Sedoheptulose 7-phosphate; a-D-Sedoheptulopyranose 7-phosphate; a-D-Sedoheptulopyranose 7-phosphoric acid; a-D-Sedoheptulose 7-phosphate; a-D-Sedoheptulose 7-phosphoric acid; a-D-altro-Hept-2-ulopyranose 7-hydrogen phosphate; a-D-altro-Hept-2-ulopyranose 7-hydrogen phosphoric acid; alpha-D-Sedoheptulose 7-phosphate; alpha-D-altro-Hept-2-ulopyranose 7-hydrogen phosphate; altro-Heptulose 7-phosphate
Source Endogenous;Escherichia Coli Metabolite;Yeast Metabolite;Food
Structure Type   Carbohydrates and carbohydrate conjugates  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic oxygen compounds
Organooxygen compounds
Carbohydrates and carbohydrate conjugates
PubChem CID
92042786
HMDB ID
HMDB0001068
Formula
C7H15O10P
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C05382
ChEBI ID
133983
FooDB ID
FDB022407
ChemSpider ID
58827526
Physicochemical Properties Molecular Weight 290.16 Topological Polar Surface Area 177
XlogP -4.6 Complexity 330
Heavy Atom Count 18 Rotatable Bond Count 4
Hydrogen Bond Donor Count 7 Hydrogen Bond Acceptor Count 10
Function
D-Sedoheptulose 7-phosphate (CAS: 2646-35-7) is an intermediate of the pentose phosphate pathway (PPP) that has two functions: (1) the generation of NADPH for reductive syntheses and oxidative stress responses within cells, and (2) the formation of ribose residues for nucleotide and nucleic acid biosynthesis. It is formed by transketolase and acted upon (degraded) by transaldolase. Sedoheptulose 7-phosphate can be increased in the blood of patients affected with a transaldolase deficiency, a genetic disorder. Sedoheptulose is a ketoheptose, a monosaccharide with seven carbon atoms and a ketone functional group. It is one of the few heptoses found in nature.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Transcription factor (TF)
            Forkhead box protein O1 (FOXO1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Overexpression of Foxo1
                      Induced Change D-Sedoheptulose 7-phosphate concentration: increase (FC = 2.90)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of Foxo1 leads to the increase of D-sedoheptulose 7-phosphate levels compared with control group.
      Transferases (EC 2)
            Transaldolase (TALDO1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Knockout of Taldo1
                      Induced Change D-Sedoheptulose 7-phosphate concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that knockout of Taldo1 leads to the increase of D-sedoheptulose 7-phosphate levels compared with control group.
References
1 Metabolomic analysis of C2C12 myoblasts induced by the transcription factor FOXO1. FEBS Lett. 2019 Jun;593(12):1303-1312.
2 Two isoforms of TALDO1 generated by alternative translational initiation show differential nucleocytoplasmic distribution to regulate the global metabolic network. Sci Rep. 2016 Oct 5;6:34648.

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