Details of Metabolite

General Information of MET (ID: META00351)
Name Tetrahydrocortisol
Synonyms   Click to Show/Hide Synonyms of This Metabolite
12-Deoxycholyltaurine; 12-Desoxycholyltaurine; 2-Hydroxy-1-(3,11,17-trihydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-ethanone; 3a,11b,17,21-Tetrahydroxy-5b-pregnan-20-one; 3a,7a-Dihydroxy-N-(2-sulfoethyl)-5b-cholan-24-amide; 3b,11b,17,21-Tetrahydroxy-5b-pregnan-20-one; 3b,11b,17a,21-Tetrahydroxy-5b-pregnan-20-ON; 5b-Tetrahydrocortisol; Acid, taurochenodeoxycholic; Chenodeoxycholate, taurine; Chenodeoxycholoyltaurine; Chenodeoxycholyltaurine; Chenyltaurine; Dihydrocortison; N-(3a,7a-Dihydroxy-5b-cholan-24-oyl)-taurine; Taurine chenodeoxycholate; Taurine chenodeoxycholic acid; Taurochenodeoxycholate; Taurochenodeoxycholic acid; Taurochenodesoxycholate; Urocortisol; tetrahydro-Cortisol
Source Endogenous;Food
Structure Type   Bile acids, alcohols and derivatives  (Click to Show/Hide the Complete Structure Type Hierarchy)
Lipids and lipid-like molecules
Steroids and steroid derivatives
Bile acids, alcohols and derivatives
PubChem CID
387316
HMDB ID
HMDB0000949
Formula
C21H34O5
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C05465
DrugBank ID
DB08833
ChEBI ID
16525
FooDB ID
FDB022335
ChemSpider ID
343282
METLIN ID
5897
Physicochemical Properties Molecular Weight 499.7 Topological Polar Surface Area 132
XlogP 3.6 Complexity 858
Heavy Atom Count 34 Rotatable Bond Count 7
Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 6
Function
Tetrahydrocortisol is the most powerful natural angiostatic steroid. It is involved in C21-Steroid hormone metabolism pathway (KEGG).
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Transferases (EC 2)
            Pyrophosphate geranylgeranyl synthase (GGPS1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of Ggps1
                      Induced Change Tetrahydrocortisol concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Metabolic liver disease [ICD-11: 5C90]
                      Details It is reported that knockout of Ggps1 leads to the decrease of tetrahydrocortisol levels compared with control group.
References
1 Conditional loss of geranylgeranyl diphosphate synthase alleviates acute obstructive cholestatic liver injury by regulating hepatic bile acid metabolism. FEBS J. 2020 Aug;287(15):3328-3345.

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