Details of Metabolite

General Information of MET (ID: META00348)
Name UDP acetylgalactosamine 4-sulfate
Synonyms   Click to Show/Hide Synonyms of This Metabolite
UDP Acetylgalactosamine-4-sulfate; UDP Acetylgalactosamine-4-sulphate; UDP-GalNAc-S; UDP-N-Acetylgalactosamine 4-sulfate; UDP-N-Acetylgalactosamine 4-sulphate; UDP-N-Acetylgalactosamine-4-sulfate; UDP-N-Acetylgalactosamine-4-sulphate; Uridine diphosphate acetylgalactosamine 4-sulphate; Uridine diphosphate acetylgalactosamine-4-sulfate; Uridine diphosphate acetylgalactosamine-4-sulphate; Uridine diphosphate-N-acetylgalactosamine 4-sulfate; Uridine diphosphate-N-acetylgalactosamine 4-sulphate; Uridine diphosphoric acid acetylgalactosamine 4-sulfuric acid; Uridine diphosphoric acid acetylgalactosamine 4-sulphuric acid; [({[(2R,3S,4R,5R)-3-[({[(2R,3R,4R,5R)-5-amino-1,2,4-trihydroxy-6,7-dioxooctan-3-yl]oxy}sulfonyl)oxy]-4-hydroxy-5-(4-hydroxy-2-oxo-1,2-dihydropyrimidin-1-yl)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]phosphonate; [({[(2R,3S,4R,5R)-3-[({[(2R,3R,4R,5R)-5-amino-1,2,4-trihydroxy-6,7-dioxooctan-3-yl]oxy}sulphonyl)oxy]-4-hydroxy-5-(4-hydroxy-2-oxo-1,2-dihydropyrimidin-1-yl)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]phosphonate; [({[(2R,3S,4R,5R)-3-[({[(2R,3R,4R,5R)-5-amino-1,2,4-trihydroxy-6,7-dioxooctan-3-yl]oxy}sulphonyl)oxy]-4-hydroxy-5-(4-hydroxy-2-oxo-1,2-dihydropyrimidin-1-yl)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]phosphonic acid
Source Endogenous;Food
Structure Type   Pyrimidine ribonucleotides  (Click to Show/Hide the Complete Structure Type Hierarchy)
Nucleosides, nucleotides, and analogues
Pyrimidine nucleotides
Pyrimidine ribonucleotides
PubChem CID
22833553
HMDB ID
HMDB0000934
Formula
C17H27N3O20P2S
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=22833553"></iframe>
3D MOL is unavailable 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C04426
FooDB ID
FDB022324
ChemSpider ID
17216024
METLIN ID
5883
Physicochemical Properties Molecular Weight 687.4 Topological Polar Surface Area 374
XlogP -10.5 Complexity 1310
Heavy Atom Count 43 Rotatable Bond Count 16
Hydrogen Bond Donor Count 9 Hydrogen Bond Acceptor Count 21
Function
Uridine diphosphate, abbreviated UDP, is a nucleotide. It is an ester of pyrophosphoric acid with the nucleoside uridine. UDP consists of the pyrophosphate group, the pentose sugar ribose, and the nucleobase uracil.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Transferases (EC 2)
            Pyridoxal kinase (PDXK) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout (CRISPR/Cas9 sgRNA) of PDXK
                      Induced Change UDP acetylgalactosamine 4-sulfate concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Acute myeloid leukaemia [ICD-11: 2A60]
                      Details It is reported that knockout of PDXK leads to the decrease of UDP acetylgalactosamine 4-sulfate levels compared with control group.
References
1 Vitamin B6 Addiction in Acute Myeloid Leukemia. Cancer Cell. 2020 Jan 13;37(1):71-84.e7.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.