Details of Metabolite

General Information of MET (ID: META00330)
Name Stearic acid
Synonyms   Click to Show/Hide Synonyms of This Metabolite
1-Heptadecanecarboxylate; 1-Heptadecanecarboxylic acid; 18:00; Acide octadecanoique; Acide stearique; Aluminum monostearate; Aluminum tristearate; Ammonium stearate; C18:0; CH3-[CH2]16-COOH; Calcium stearate; FA(18:0); Magnesium stearate; N-Octadecanoate; N-Octadecanoic acid; Octadecanoate; Octadecanoic acid; Octadecansaeure; Octadecoate; Octadecoic acid; Oktadekansaeure; Sodium stearate; Stearate; Stearex beads; Stearic acid cherry; Stearinsaeure; Stearophanate; Stearophanic acid; Zinc stearate
Source Endogenous;Escherichia Coli Metabolite;Yeast Metabolite;Fatty acyls;Food;Drug;Toxins/Pollutant;Cosmetic;Food additives;TCM Ingredients;Microbial
Structure Type   Fatty acids and conjugates  (Click to Show/Hide the Complete Structure Type Hierarchy)
Lipids and lipid-like molecules
Fatty Acyls
Fatty acids and conjugates
PubChem CID
5281
HMDB ID
HMDB0000827
Formula
C18H36O2
Structure
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3D MOL is unavailable 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C01530
DrugBank ID
DB03193
ChEBI ID
28842
FooDB ID
FDB031183
ChemSpider ID
5091
METLIN ID
189
Physicochemical Properties Molecular Weight 284.5 Topological Polar Surface Area 37.3
XlogP 7.4 Complexity 202
Heavy Atom Count 20 Rotatable Bond Count 16
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 2
Function
Stearic acid, also called octadecanoic acid, is one of the useful types of saturated fatty acids that comes from many animal and vegetable fats and oils. It is a waxy solid, and its chemical formula is CH3(CH2)16COOH. Its name comes from the Greek word stear, which means tallow. Its IUPAC name is octadecanoic acid. -- Wikipedia.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Transcription factor (TF)
            Hypoxia-inducible factor 1-alpha (HIF1A) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of HIF1A
                      Induced Change Stearic acid concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Colorectal cancer [ICD-11: 2B91]
                      Details It is reported that knockout of HIF1A leads to the increase of stearic acid levels compared with control group.
      Transferases (EC 2)
            Deacetylase sirtuin-5 (SIRT5) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Knockout of Sirt5
                      Induced Change Stearic acid concentration: increase (FC = 1.17)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that knockout of Sirt5 leads to the increase of stearic acid levels compared with control group.
References
1 Hypoxia induces a lipogenic cancer cell phenotype via HIF1-dependent and -independent pathways. Oncotarget. 2015 Feb 10;6(4):1920-41.
2 Metabolomics Based Identification of SIRT5 and Protein Kinase C Epsilon Regulated Pathways in Brain. Front Neurosci. 2018 Jan 30;12:32.

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