Details of Metabolite

General Information of MET (ID: META00304)
Name 1-Methylnicotinamide
Synonyms   Click to Show/Hide Synonyms of This Metabolite
1-Methyl-3-carbamoylpyridinium; 1-Methyl-3-carbamoylpyridinium cation; 1-Methylnicotinamide cation; 3-(Aminocarbonyl)-1-methylpyridinium; 3-Amido-N-methylpyridinium: 1-methyl-3-pyridinecarboxamide; 3-Carbamoyl-1-methyl-pyridinium; I-methyl nicotinamide', N'-methylnicotinamide, N'Methylnicotinamide, 'N-1-Methylnicotinamide; N(1)-Methylnicotinamide; N(1)-Methylnicotinamide bromide; N(1)-Methylnicotinamide chloride; N(1)-Methylnicotinamide cyanide; N(1)-Methylnicotinamide fluoride; N(1)-Methylnicotinamide iodide; N(1)-Methylnicotinamide iodide, 3-(aminocarbonyl-13C)-labeled; N(1)-Methylnicotinamide methylsulfate; N(1)-Methylnicotinamide perchlorate; N(1)-Methylnicotinamide tetrafluoroborate (1-); N-Methyl-3-carbamidopyridinium; N-Methyl-3-carbamoylpyridinium ion; N1-Methylnicotinamide; Trigonellamide chloride; Trigonellinamide
Source Endogenous;Escherichia Coli Metabolite;Yeast Metabolite;Food;Microbial
Structure Type   Pyridinecarboxylic acids and derivatives  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organoheterocyclic compounds
Pyridines and derivatives
Pyridinecarboxylic acids and derivatives
PubChem CID
457
HMDB ID
HMDB0000699
Formula
C7H9N2O
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C02918
DrugBank ID
DB11710
ChEBI ID
16797
FooDB ID
FDB022188
ChemSpider ID
444
METLIN ID
5667
Physicochemical Properties Molecular Weight 137.16 Topological Polar Surface Area 47
XlogP -0.1 Complexity 136
Heavy Atom Count 10 Rotatable Bond Count 1
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 1
Function
1-Methylnicotinamide is a metabolite of nicotinamide and is produced primarily in the liver. It has anti-inflammatory properties. It is a product of nicotinamide N-methyltransferase [EC 2.1.1.1] in the pathway of nicotinate and nicotinamide metabolism (KEGG). 1-Methylnicotinamide may be an endogenous activator of prostacyclin production and thus may regulate thrombotic as well as inflammatory processes in the cardiovascular system.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Transcription factor (TF)
            Forkhead box protein O1 (FOXO1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Overexpression of Foxo1
                      Induced Change 1-Methylnicotinamide concentration: decrease (FC = 0.60)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of Foxo1 leads to the decrease of 1-methylnicotinamide levels compared with control group.
References
1 Metabolomic analysis of C2C12 myoblasts induced by the transcription factor FOXO1. FEBS Lett. 2019 Jun;593(12):1303-1312.

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