Details of Metabolite

General Information of MET (ID: META00280)
Name Erythronic acid
Synonyms   Click to Show/Hide Synonyms of This Metabolite
(R*,r*)-2,3,4-trihydroxy-butanoate; (R*,r*)-2,3,4-trihydroxy-butanoic acid; 2,3,4-Trihydroxybutanoate; 2,3,4-Trihydroxybutanoic acid; D-Erythronate; Erythro-2,3,4-trihydroxybutyrate; Erythro-2,3,4-trihydroxybutyric acid; Erythronate; Erythronic acid
Source Endogenous;Food
Structure Type   Carbohydrates and carbohydrate conjugates  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic oxygen compounds
Organooxygen compounds
Carbohydrates and carbohydrate conjugates
PubChem CID
2781043
HMDB ID
HMDB0000613
Formula
C4H8O5
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
ChEBI ID
37655
FooDB ID
FDB022143
ChemSpider ID
2061231
METLIN ID
5586
Physicochemical Properties Molecular Weight 136.1 Topological Polar Surface Area 98
XlogP -2.1 Complexity 101
Heavy Atom Count 9 Rotatable Bond Count 3
Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 5
Function
Erythronic acid is a sugar component of aqueous humour (eye). It may be derived from glycated proteins or from degradation of ascorbic acid. Erythronic acid is a normal organic acid present in a healthy adult and pediatric population. It has been found in urine, plasma, CSF, and synovial fluid. Erythronic acid is formed when N-acetyl-D-glucosamine (GlcNAc) is oxidized. GlcNAc is a constituent of hyaluronic acid (HA), a polysaccharide consisting of alternating units of glucuronic acid and GlcNAc, present as an aqueous solution in synovial fluid. In the synovial fluid of patients suffering from rheumatoid arthritis, HA is thought to be degraded either by radicals generated by Fenton chemistry (Fe2+/H2O2) or by NaOCl generated by myeloperoxidase.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Hydrolases (EC 3)
            Alpha-N-acetylglucosaminidase (NAGLU) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of Naglu
                      Induced Change Erythronic acid concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Lysosomal storage diseases [ICD-11: 5C56]
                      Details It is reported that knockout of Naglu leads to the decrease of erythronic acid levels compared with control group.
References
1 Near-Complete Correction of Profound Metabolomic Impairments Corresponding to Functional Benefit in MPS IIIB Mice after IV rAAV9-hNAGLU Gene Delivery. Mol Ther. 2017 Mar 1;25(3):792-802.

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