Details of Metabolite

General Information of MET (ID: META00262)
Name Ribitol
Synonyms   Click to Show/Hide Synonyms of This Metabolite
(2R,3S,4S)-Pentane-1,2,3,4,5-pentol; 1,2,3,4,5-Pentanepentol; Adonit; Adonite; Adonitol; D-Adonitol; D-Ribitol; L-Ribitol; Pentitol
Source Endogenous;Escherichia Coli Metabolite;Food;Microbial
Structure Type   Carbohydrates and carbohydrate conjugates  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic oxygen compounds
Organooxygen compounds
Carbohydrates and carbohydrate conjugates
HMDB ID
HMDB0000508
Formula
C5H12O5
Structure
2D MOL
KEGG ID
C00474
ChEBI ID
15963
FooDB ID
FDB022083
ChemSpider ID
10254628
METLIN ID
316
Function
Ribitol is a metabolic end product formed by the reduction of ribose in human fibroblasts and erythrocytes (pentitol, sugar alcohol, polyol). Export of ribitol across the cell membrane indicates that can be cleared from the body without metabolic conversion. Several inborn errors of metabolism with abnormal polyol concentrations in body fluids are known to date, such as ribose-5-phosphate isomerase deficiency. Most of these defects can be diagnosed by the assessment of urinary concentrations of polyols. Ribitol is normally absent in Breast milk.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Hydrolases (EC 3)
            GTPase KRas (KRAS) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Overexpression of KRAS
                      Induced Change Ribitol concentration: decrease (FC = 0.56)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Lung cancer [ICD-11: 2C25]
                      Details It is reported that overexpression of KRAS leads to the decrease of ribitol levels compared with control group.
References
1 Capturing the metabolomic diversity of KRAS mutants in non-small-cell lung cancer cells. Oncotarget. 2014 Jul 15;5(13):4722-31.

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