Details of Metabolite

General Information of MET (ID: META00248)
Name 2-Phosphoglyceric acid
Synonyms   Click to Show/Hide Synonyms of This Metabolite
2-(Dihydrogen phosphate)glycerate; 2-(Dihydrogen phosphate)glyceric acid; 2-Phospho-D-glycerate; 2-Phospho-DL-glyceric acid; 2-Phosphoglycerate; 2-Phosphoglycerate, (+-)-isomer; 2-Phosphoglycerate, (R)-isomer; 2-Phosphoglycerate, (S)-isomer; 2-Phosphoglycerate, monosodium salt; 2-Phosphoglyceric acid; 2-p-D-Glycerate; 2-p-D-Glyceric acid; 2-p-Glycerate; 2-p-Glyceric acid; 3-Hydroxy-2-(phosphonooxy)propanoate; 3-Hydroxy-2-(phosphonooxy)propanoic acid; 3-Hydroxy-2-phosphonooxypropanoate; 3-Hydroxy-2-phosphonooxypropanoic acid; DL-2-Phosphoglycerate; Glycerate 2-phosphate; Glyceric acid 2-phosphate; Phosphoglycerate
Source Endogenous;Escherichia Coli Metabolite;Food;Microbial
Structure Type   Carbohydrates and carbohydrate conjugates  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic oxygen compounds
Organooxygen compounds
Carbohydrates and carbohydrate conjugates
PubChem CID
59
HMDB ID
HMDB0000362
Formula
C3H7O7P
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
ChEBI ID
24344
FooDB ID
FDB023161
ChemSpider ID
58
METLIN ID
5351
Physicochemical Properties Molecular Weight 186.06 Topological Polar Surface Area 124
XlogP -2.6 Complexity 182
Heavy Atom Count 11 Rotatable Bond Count 4
Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 7
Function
2-Phosphoglyceric acid (2PGA) is a glyceric acid which serves as the substrate in the ninth step of glycolysis. It is catalyzed by enolase into phosphoenolpyruvate (PEP), the penultimate step in the conversion of glucose to pyruvate. Enolase catalyzes the beta-elimination reaction in a stepwise manner wherein OH- is eliminated from C3 of a discrete carbanion (enolate) intermediate. This intermediate is created by removal of the proton from C2 of 2PGA by a base in the active site.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Transferases (EC 2)
            Sphingosine kinase 1 (SPHK1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of Sphk1
                      Induced Change 2-Phosphoglyceric acid concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Chronic kidney disease [ICD-11: GB61]
                      Details It is reported that knockout of Sphk1 leads to the decrease of 2-phosphoglyceric acid levels compared with control group.
            Transaldolase (TALDO1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Knockout of Taldo1
                      Induced Change 2-Phosphoglyceric acid concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that knockout of Taldo1 leads to the increase of 2-phosphoglyceric acid levels compared with control group.
References
1 Erythrocyte Metabolic Reprogramming by Sphingosine 1-Phosphate in Chronic Kidney Disease and Therapies. Circ Res. 2020 Jul 17;127(3):360-375.
2 Two isoforms of TALDO1 generated by alternative translational initiation show differential nucleocytoplasmic distribution to regulate the global metabolic network. Sci Rep. 2016 Oct 5;6:34648.

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