Details of Metabolite

General Information of MET (ID: META00216)
Name Quinolinic acid
Synonyms   Click to Show/Hide Synonyms of This Metabolite
2,3-Pyridinedicarboxylate; 2,3-Pyridinedicarboxylic acid; 3,4-Pyridinedicarboxylic acid; Pyridin-2,3-dicarbonsaeure; Pyridine-2,3-carboxylate; Pyridine-2,3-dicarboxylate; Pyridine-2,3-dicarboxylic acid; Quinolinate; Quinolinic acid
Source Endogenous;Escherichia Coli Metabolite;Yeast Metabolite;Food;Drug;Cosmetic;Microbial
Structure Type   Pyridinecarboxylic acids and derivatives  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organoheterocyclic compounds
Pyridines and derivatives
Pyridinecarboxylic acids and derivatives
PubChem CID
1066
HMDB ID
HMDB0000232
Formula
C7H5NO4
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=1066"></iframe>
3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C03722
DrugBank ID
DB01796
ChEBI ID
16675
FooDB ID
FDB031142
ChemSpider ID
144985
Physicochemical Properties Molecular Weight 167.12 Topological Polar Surface Area 87.5
XlogP 0.2 Complexity 204
Heavy Atom Count 12 Rotatable Bond Count 2
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 5
Function
Quinolinic acid, also known as quinolinate, belongs to the class of organic compounds known as pyridinecarboxylic acids. Pyridinecarboxylic acids are compounds containing a pyridine ring bearing a carboxylic acid group. Quinolinic acid is a very strong basic compound (based on its pKa). Quinolinic acid has been detected, but not quantified in, several different foods, such as Ceylon cinnamons, pitanga, Oregon yampahs, red bell peppers, and durians. This could make quinolinic acid a potential biomarker for the consumption of these foods. Quinolinic acid is a metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS. Quinolinic acid is a product of tryptophan metabolism that can act as an endogenous brain excitotoxin when released by activated macrophages.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Oxidoreductases (EC 1)
            3-hydroxyanthranilate oxygenase (HAAO) Click to Show/Hide the Full List of Regulating Pair(s):   2 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair (1) Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Mutation (c.483dupT) of HAAO
                      Induced Change Quinolinic acid concentration: decrease (FC= 0.45)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Hereditary methemoglobinemia [ICD-11: 3A92]
                      Details It is reported that mutation (c.483dupT) of HAAO leads to the decrease of quinolinic acid levels compared with control group.
               Regulating Pair (2) Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Mutation (c.558G-A) of HAAO
                      Induced Change Quinolinic acid concentration: decrease (FC= 0.26)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Hereditary methemoglobinemia [ICD-11: 3A92]
                      Details It is reported that mutation (c.558G-A) of HAAO leads to the decrease of quinolinic acid levels compared with control group.
References
1 NAD Deficiency, Congenital Malformations, and Niacin Supplementation. N Engl J Med. 2017 Aug 10;377(6):544-552.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.