Details of Metabolite

General Information of MET (ID: META00198)
Name Anserine
Synonyms   Click to Show/Hide Synonyms of This Metabolite
Balanine; Beta Alanyl 3 methylhistidine; Beta-Alanyl-3-methylhistidine; L-Anserine; L-N-b-Alanyl-3-methyl-histidine; L-N-beta-Alanyl-3-methyl-histidine; N-b-Alanyl-3-methyl-L-histidine; N-beta-Alanyl-3-methyl-L-histidine; Ophidine; beta-Alanyl-3-methyl-L-histidine; beta-Alanyl-N(pai)-methyl-L-histidine
Source Endogenous;Escherichia Coli Metabolite;Yeast Metabolite;Food;Cosmetic;Microbial
Structure Type   Hybrid peptides  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic acids and derivatives
Peptidomimetics
Hybrid peptides
PubChem CID
112072
HMDB ID
HMDB0000194
Formula
C10H16N4O3
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C01262
ChEBI ID
18323
FooDB ID
FDB021903
ChemSpider ID
100482
METLIN ID
5209
Physicochemical Properties Molecular Weight 240.26 Topological Polar Surface Area 110
XlogP -4 Complexity 285
Heavy Atom Count 17 Rotatable Bond Count 6
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 5
Function
This dipeptide is normally absent from human tissues and body fluids, and its appearance there is an artifact of diet (Proc Soc Pediatr Res 134, 1967.) and serum carnosinase deficiency. (OMIM 212200) Anserine is present in the skeletal muscle of birds and certain species of mammals, notably the rabbit, rat, and whale, contains anserine. (Proc Soc Pediatr Res 134, 1967) The methyl group of anserine is added to carnosine by the enzyme S-adenosylmethionine: carnosine N-methyltransferase. (J Biol Chem 237:1207, 1962.). Anserine is a biomarker for the consumption of meat, especially chicken.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Hydrolases (EC 3)
            Carnosine dipeptidase 1 (CNDP1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of Cndp1
                      Induced Change Anserine concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that knockout of Cndp1 leads to the increase of anserine levels compared with control group.
      Pore-forming PNC peptide (PNC)
            Cellular tumor antigen p53 (TP53) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Knockout of TP53
                      Induced Change Anserine concentration: decrease (Log2 FC=0.59)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Colon cancer [ICD-11: 2B90]
                      Details It is reported that knockout of TP53 leads to the decrease of anserine levels compared with control group.
References
1 A Global Cndp1-Knock-Out Selectively Increases Renal Carnosine and Anserine Concentrations in an Age- and Gender-Specific Manner in Mice. Int J Mol Sci. 2020 Jul 10;21(14):4887.
2 Integrative omics analysis of p53-dependent regulation of metabolism. FEBS Lett. 2018 Feb;592(3):380-393.

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