Details of Metabolite

General Information of MET (ID: META00189)
Name Inosinic acid
Synonyms   Click to Show/Hide Synonyms of This Metabolite
2'-Inosine-5'-monophosphate, 5'-IMP, 5'-Inosinate, 5'-Inosine monophosphate, 5'-Inosinic acid, Hypoxanthosine 5'-monophosphate, Inosine 5'-monophosphate, Inosine 5'-phosphate, 'Inosine monophosphate; Acid, inosinic; Acids, inosinic; IMP', Inosine-5'-monophosphate, 'Inosinic acids; Inosinate; Inosinate, sodium; Ribosylhypoxanthine monophosphate', 2'-Inosine-5'-monophosphoric acid, 5'-Inosine monophosphoric acid, Hypoxanthosine 5'-monophosphoric acid, Inosine 5'-monophosphoric acid, Inosine 5'-phosphoric acid, 'Inosine monophosphoric acid; Ribosylhypoxanthine monophosphoric acid; Sodium inosinate; monoPhosphate, inosine; monoPhosphate, ribosylhypoxanthine
Source Aromatic heteropolycyclic compounds
Structure Type   Purine ribonucleotides  (Click to Show/Hide the Complete Structure Type Hierarchy)
Nucleosides, nucleotides, and analogues
Purine nucleotides
Purine ribonucleotides
PubChem CID
8582
HMDB ID
HMDB0000175
Formula
C10H13N4O8P
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C00130
DrugBank ID
DB04566
ChEBI ID
17202
FooDB ID
FDB021901
ChemSpider ID
8264
METLIN ID
5196
Physicochemical Properties Molecular Weight 348.206 Topological Polar Surface Area N.A.
XlogP N.A. Complexity N.A.
Heavy Atom Count N.A. Rotatable Bond Count N.A.
Hydrogen Bond Donor Count N.A. Hydrogen Bond Acceptor Count N.A.
Function
Inosinic acid is a purine nucleotide which has hypoxanthine as the base and one phosphate group esterified to the sugar moiety. Inosinic acid is a nucleotide present in muscle and other tissues. It is formed by the deamination of AMP and when hydrolysed produces inosine. Inosinic acid is the ribonucleotide of hypoxanthine and is the first compound formed during the synthesis of purine.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Mitochondrial carrier (MC)
            Solute carrier family 25 member 36 (SLC25A36) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Recombinant protein addition of SLC25A36
                      Induced Change Inosinic acid concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that recombinant protein addition of SLC25A36 leads to the increase of inosinic acid levels compared with control group.
      Nitrogen permease regulator (NPR)
            Natriuretic peptide receptor B (NPR2) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Deletion of NPR2
                      Induced Change Inosinic acid concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that deletion of NPR2 leads to the decrease of inosinic acid levels compared with control group.
      Pore-forming PNC peptide (PNC)
            Cellular tumor antigen p53 (TP53) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [3]
                      Introduced Variation Knockout of TP53
                      Induced Change Inosinic acid concentration: decrease (Log2 FC=0.74)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Colon cancer [ICD-11: 2B90]
                      Details It is reported that knockout of TP53 leads to the decrease of inosinic acid levels compared with control group.
References
1 The human SLC25A33 and SLC25A36 genes of solute carrier family 25 encode two mitochondrial pyrimidine nucleotide transporters. J Biol Chem. 2014 Nov 28;289(48):33137-48.
2 Npr2 inhibits TORC1 to prevent inappropriate utilization of glutamine for biosynthesis of nitrogen-containing metabolites. Sci Signal. 2014 Dec 16;7(356):ra120.
3 Integrative omics analysis of p53-dependent regulation of metabolism. FEBS Lett. 2018 Feb;592(3):380-393.

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