Details of Metabolite

General Information of MET (ID: META00170)
Name Guanidoacetic acid
Synonyms   Click to Show/Hide Synonyms of This Metabolite
(Carboxymethyl)-guanidine; 2-[[Amino(imino)methyl]amino]acetate; 2-[[Amino(imino)methyl]amino]acetic acid; Betacyamine; Betasyamine; Glycocyamine; Glycocyamine monohydrochloride; Glycocyamine, 2-(14)C-labeled; Glycocyamine, ion (1-); Guanidineacetate; Guanidineacetic acid; Guanidinoacetate; Guanidinoacetic acid; Guanidoacetate; Guanidylacetate; Guanidylacetic acid; Guanyl glycine; N-(Carbamimidoyl)glycine; N-Amidino-glycine; N-Amidinoglycine; N-[Amino(imino)methyl]glycine; [(Aminoiminomethyl)amino]-acetate; [(Aminoiminomethyl)amino]-acetic acid; a-Guanidinoacetate; a-Guanidinoacetic acid; alpha-Guanidinoacetate; alpha-Guanidinoacetic acid; b-Guanidinoacetate; b-Guanidinoacetic acid; beta-Guanidinoacetate; beta-Guanidinoacetic acid
Source Endogenous;Food;Drug;Toxins/Pollutant
Structure Type   Amino acids, peptides, and analogues  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic acids and derivatives
Carboxylic acids and derivatives
Amino acids, peptides, and analogues
PubChem CID
763
HMDB ID
HMDB0000128
Formula
C3H7N3O2
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C00581
DrugBank ID
DB02751
ChEBI ID
16344
FooDB ID
FDB021898
ChemSpider ID
743
METLIN ID
5163
Physicochemical Properties Molecular Weight 117.11 Topological Polar Surface Area 102
XlogP -1.6 Complexity 116
Heavy Atom Count 8 Rotatable Bond Count 2
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 3
Function
Guanidoacetic acid is a metabolite in the Urea cycle and metabolism of amino groups, and in the metabolic pathways of several amino acids. This includes glycine, serine, threonine, arginine and proline metabolism. Guanidinoacetic acid is also a precursor of creatine, an essential substrate for muscle energy metabolism. Guanidoacetic acid has been identified as a uremic toxin according to the European Uremic Toxin Working Group.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Transcription factor (TF)
            Forkhead box protein O1 (FOXO1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Overexpression of Foxo1
                      Induced Change Guanidoacetic acid concentration: decrease (FC = 0.40)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of Foxo1 leads to the decrease of guanidoacetic acid levels compared with control group.
References
1 Metabolomic analysis of C2C12 myoblasts induced by the transcription factor FOXO1. FEBS Lett. 2019 Jun;593(12):1303-1312.

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