Details of Metabolite

General Information of MET (ID: META00133)
Name Dihydrobiopterin
Synonyms   Click to Show/Hide Synonyms of This Metabolite
7,8-DIHYDROBIOPTERIN; 7,8-Dihydro-L-biopterin; BH2; Dihydrobiopterin; L-Erythro-Q-dihydrobiopterin; L-erythro-7,8-Dihydrobiopterin; L-erythro-Dihydrobiopterin; Q-BH2; Quinonoid dihydrobiopterin
Source Endogenous;Yeast Metabolite;Food;Microbial
Structure Type   Pterins and derivatives  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organoheterocyclic compounds
Pteridines and derivatives
Pterins and derivatives
PubChem CID
119055
HMDB ID
HMDB0000038
Formula
C9H13N5O3
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C02953
DrugBank ID
DB04400
ChEBI ID
43029
FooDB ID
FDB021884
ChemSpider ID
106382
Physicochemical Properties Molecular Weight 239.2312 Topological Polar Surface Area N.A.
XlogP N.A. Complexity N.A.
Heavy Atom Count N.A. Rotatable Bond Count N.A.
Hydrogen Bond Donor Count N.A. Hydrogen Bond Acceptor Count N.A.
Function
Dihydrobiopterin, also known as BH2, belongs to the class of organic compounds known as biopterins and derivatives. These are coenzymes containing a 2-amino-pteridine-4-one derivative. They are mainly synthesized in several parts of the body, including the pineal gland. Dihydrobiopterin is an extremely weak basic (essentially neutral) compound (based on its pKa). Dihydrobiopterin exists in all eukaryotes, ranging from yeast to humans. Dihydrobiopterin can be biosynthesized from tetrahydrobiopterin through its interaction with the enzyme dihydropteridine reductase. In humans, dihydrobiopterin is involved in the metabolic disorder hyperphenylalaninemia due to dihydropteridine reductase (DHPR) deficiency.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Hydrolases (EC 3)
            Alpha-N-acetylglucosaminidase (NAGLU) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of Naglu
                      Induced Change Dihydrobiopterin concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Lysosomal storage diseases [ICD-11: 5C56]
                      Details It is reported that knockout of Naglu leads to the decrease of dihydrobiopterin levels compared with control group.
References
1 Near-Complete Correction of Profound Metabolomic Impairments Corresponding to Functional Benefit in MPS IIIB Mice after IV rAAV9-hNAGLU Gene Delivery. Mol Ther. 2017 Mar 1;25(3):792-802.

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