| General Information of MET (ID: META00123) |
| Name |
4-Pyridoxic acid
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| Synonyms |
Click to Show/Hide Synonyms of This Metabolite
2-Methyl-3-hydroxy-4-carboxy-5-hydroxymethylpyridine; 3-Hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxylate; 3-Hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxylic acid; 3-Hydroxy-5-(hydroxymethyl)-2-methyl-isonicotinate; 3-Hydroxy-5-(hydroxymethyl)-2-methyl-isonicotinic acid; 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinate; 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinic acid; 3-Hydroxy-5-hydroxymethyl-2-methyl-isonicotinate; 3-Hydroxy-5-hydroxymethyl-2-methyl-isonicotinic acid; 3-Hydroxy-5-hydroxymethyl-2-methyl-isonicotinsaeure; 4 Pyridoxic acid; 4 Pyridoxinic acid; 4 Pyridoxylic acid; 4-Pyridoxate; 4-Pyridoxinate; 4-Pyridoxinecarboxylate; 4-Pyridoxinecarboxylic acid; 4-Pyridoxinic acid; 4-Pyridoxinsaeure; 4-Pyridoxylate; 4-Pyridoxylic acid; Pyridoxate; Pyridoxic acid; Pyridoxinecarboxylic acid
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| Source |
Endogenous;Escherichia Coli Metabolite;Food;Microbial
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| Structure Type |
Pyridinecarboxylic acids and derivatives (Click to Show/Hide the Complete Structure Type Hierarchy)
Organoheterocyclic compounds
Pyridines and derivatives
Pyridinecarboxylic acids and derivatives
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| PubChem CID |
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| HMDB ID |
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| Formula |
C8H9NO4
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| Structure |
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3D MOL
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2D MOL
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Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
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| KEGG ID |
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| ChEBI ID |
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| FooDB ID |
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| ChemSpider ID |
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| METLIN ID |
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| Physicochemical Properties |
Molecular Weight |
183.16 |
Topological Polar Surface Area |
90.6 |
| XlogP |
0.1 |
Complexity |
197 |
| Heavy Atom Count |
13 |
Rotatable Bond Count |
2 |
| Hydrogen Bond Donor Count |
3 |
Hydrogen Bond Acceptor Count |
5 |
| Function |
4-Pyridoxic acid is the catabolic product of vitamin B6 (also known as pyridoxine, pyridoxal and pyradoxamine) which is excreted in the urine. Urinary levels of 4-pyridoxic acid are lower in females than in males and will be reduced in persons with riboflavin deficiency. 4-Pyridoxic acid is formed by the action of aldehyde oxidase I (an endogenous enzyme) and by microbial enzymes (pyridoxal 4-dehydrogenase), an NAD-dependent aldehyde dehydrogenase. 4-pyridoxic acid can be further broken down by the gut microflora via 4-pyridoxic acid dehydrogenase. This enzyme catalyzes the four electron oxidation of 4-pyridoxic acid to 3-hydroxy-2-methylpyridine-4,5-dicarboxylate, using nicotinamide adenine dinucleotide as a cofactor.
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Regulatory Network
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Induced Change
