Details of Metabolite

General Information of MET (ID: META00086)
Name Protocatechuic acid 4-O-sulfate
Synonyms   Click to Show/Hide Synonyms of This Metabolite
3,4-DHBA sulfate; 3,4-DHBA sulphate; 3-HSOB; 3-Hydroxy-4-(sulfooxy)benzoic acid; 3-Hydroxy-sulfonyloxybenzoic acid; Protocatechuate 4-O-sulfate; Protocatechuate 4-O-sulphate; Protocatechuic acid 4-O-sulfuric acid; Protocatechuic acid 4-O-sulphuric acid; Protocatechuic acid sulfate; Protocatechuic acid sulphate
Source Aromatic homomonocyclic compounds
Structure Type   Arylsulfates  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic acids and derivatives
Organic sulfuric acids and derivatives
Arylsulfates
HMDB ID
HMDB0240382
Formula
C7H6O7S
Structure
2D MOL
FooDB ID
FDB031321
Function
Protocatechuic acid sulfate, also known as 3,4-DHBA sulfate, is an endogenous phenolic acid found to be elevated in mice urine after rye-bran supplemented diets which makes this compound a potential urinary biomarker of whole grain intake.
Regulatory Network
Full List of Protein(s) Regulated by This Metabolite
      Leptin (Lep)
            Leptin (LEP) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Protocatechuic acid 4-O-sulfate addition (9 hours)
                      Induced Change LEP protein expression levels: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that protocatechuic acid 4-O-sulfate addition causes the increase of LEP protein expression compared with control group.
References
1 Leucine in food mediates some of the postprandial rise in plasma leptin concentrations. Am J Physiol Endocrinol Metab. 2006 Sep;291(3):E621-30.

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