Details of Metabolite

General Information of MET (ID: META00032)
Name CDP-glycerol
Synonyms   Click to Show/Hide Synonyms of This Metabolite
CDP Glycerols; Cytidine diphosphate glycerol; Cytidine diphosphate glycerol, (R)-isomer
Source Endogenous;Food
Structure Type   CDP-glycerols  (Click to Show/Hide the Complete Structure Type Hierarchy)
Lipids and lipid-like molecules
Glycerophospholipids
CDP-glycerols
PubChem CID
439249
HMDB ID
HMDB0059599
Formula
C12H21N3O13P2
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C00513
ChEBI ID
17885
FooDB ID
FDB030719
Physicochemical Properties Molecular Weight 477.25 Topological Polar Surface Area 251
XlogP -5.3 Complexity 791
Heavy Atom Count 30 Rotatable Bond Count 10
Hydrogen Bond Donor Count 7 Hydrogen Bond Acceptor Count 13
Function
Cdp-glycerol is part of the Purine metabolism, and Glycerophospholipid metabolism pathways. It is a substrate for: Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Transferases (EC 2)
            Arylamine N-acetyltransferase 1 (NAT1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of NAT1
                      Induced Change CDP-glycerol concentration: decrease (FC = 0.4)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Breast cancer [ICD-11: 2C60]
                      Details It is reported that knockout of NAT1 leads to the decrease of CDP-glycerol levels compared with control group.
References
1 CRISPR/Cas9 knockout of human arylamine N-acetyltransferase 1 in MDA-MB-231 breast cancer cells suggests a role in cellular metabolism. Sci Rep. 2020 Jun 17;10(1):9804.

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